Knowledge Hub

Insights &
Research

Stay at the forefront of exosome science. Explore our latest publications, research updates, and industry perspectives from the Yanhua Bio scientific team.

Peer-Reviewed
Research Output

Our scientific team publishes in leading journals, advancing the collective understanding of exosome biology and therapeutic applications.

Nature Biotechnology2025

Scalable production of engineered exosomes using 3D perfusion bioreactor technology: a manufacturing paradigm shift

Zhang Y, Li W, Chen X, et al. Demonstrating 50-fold yield improvement with maintained particle quality and biological activity across 12 cell line sources.

ACS Nano2025

Surface-engineered exosomes with dual-ligand display achieve enhanced tumor penetration and therapeutic efficacy in solid tumor models

Wang H, Liu J, Zhang Y, et al. Novel targeting strategy achieving 25x tumor enrichment with deep parenchymal penetration confirmed by multiphoton imaging.

Biomaterials2024

Exosome-mediated collagen remodeling: mechanisms and therapeutic potential for skin rejuvenation and wound healing

Chen L, Zhang Y, Zhao M, et al. Comprehensive characterization of fibroblast reprogramming through miR-29 family delivery via MSC-derived exosomes.

J Extracellular Vesicles2024

Standardized quality control framework for therapeutic exosome production: a multi-center validation study

Li W, Zhang Y, et al. Establishing 47-point QC protocol validated across 9 manufacturing sites with less than 10% batch-to-batch variability.

Latest Developments

June 2025

IND Application Filed for YH-T01

First-in-class exosome therapeutic for tumor microenvironment modulation enters Phase I preparation, marking a major milestone for our oncology pipeline.

May 2025

GMP Facility Expansion

New 5,000 sqm cleanroom facility with 12 independent production lines achieves GMP certification, tripling our manufacturing capacity for clinical supply.

April 2025

Hospital Network Expansion

Three new Class-A tertiary hospitals join our clinical research network, expanding multi-center trial capabilities across northern and western China.

30+
Publications
15
Impact Factor Avg
12
International Patents
5
Conference Awards

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